Submit an IACUC Protocol Application

Process arrow "Is an IACUC application needed?" is not highlighted
Process arrow "Submit an application" is highlighted
Process arrow "IACUC review and approval" is not highlighted
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Process arrow "Modify/amend a protocol" is not highlighted
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The protocol principal investigator (PI) is responsible for satisfying the elements of a protocol. 

Other offices at UC Santa Cruz may be involved in developing parts of the protocol. Most commonly these are:

  • EH&S (Environmental Health and Safety)
  • OSP (Office of Sponsored Projects)
  • OES (Office of Emergency Services)

Protocols cannot be approved until both CITI training and risk assessments (OHSS enrollment) have been completed.

Elements of a protocol
  • Training, regulatory and animal
    • Online CITI Training
    • In-lab training, which refers to a description of the experience of the research staff included in the protocol with the species and techniques described. It is acceptable to write that a senior experienced lab member will train and supervise others.
    • Note: Personnel who are not affiliated with UC Santa Cruz may be exempted by confirmation by the PI of animal care and use training at the individual’s home institution.
  • Safety for personnel
    • Occupational Health Surveillance System (OHSS) assessment/clearance
    • Completion of the BUA (Biological Use Authorization) with approval by the IBC (Institutional Biosafety Committee), as needed 
    • A field work safety plan, which EH&S manages, as needed
    • Note: Personnel who are not affiliated with UC Santa Cruz may be exempted by confirmation by the PI of occupational health and safety assessment training at the individual’s home institution.
  • Engagement with the veterinarian
    • When surgery is part of the protocol.
    • When selecting animal housing area(s) not previously approved.
  • Establishing the planned location of the animal work. Consult with:
    • The animal resources manager for Biomed vivarium studies.
    • Department heads for PI-managed spaces.
    • Local authorities for wildlife research work/permit requirements.

Choosing the correct protocol form

New projects/protocols or protocols approaching expiration dates: expand to see the four IACUC application form types.

Because invertebrate animals are not included by regulations, the term “vertebrate animal” is used in the descriptions below. A PI wanting an invertebrate study to be reviewed by the IACUC may use any of the forms as appropriate.

Full Use Biomedical Protocol Application Form(.docx) or FUB

  • Completed for: typically traditional biomedical research that involves
    • any contact with any living vertebrate animal by any personnel, or 
    • any alteration of animal environment(s) during observational work.
  • Species include: generally mice, rats, zebrafish, and small birds (e.g., canaries, zebra finches). 
  • Locations include: the Biomed vivarium and PI-managed lab spaces.

Full Use Non-Biomedical Protocol Application Form(.docx) or FUNB

  • Completed for: typically for non-biomedical research that involves
    1. any contact with any living vertebrate animal by any personnel, or 
    2. any alteration of animal environment(s) while engaged in non-biomedical research.
  • Species include: generally marine mammals, marine fishes, and reptiles.  
  • Locations include: work in the field (aquatic, terrestrial, and aerial), Coastal Science Campus, and in other PI-managed lab spaces.

Vertebrate Sample Use Protocol Application Form(.docx) or VSU

  • Completed for: research with animal samples (tissues, scat, blood derivatives) involving no contact with any living vertebrates. 
  • Species include: everything from mice to non-human primates to marine mammals. 
  • Locations include: work in field settings.

Observational Protocol Application Form(.docx) or OBS

  • Completed for: research that only involves the observation of animal subjects with no contact.
    • If the research involves the observation of vertebrates with “material alteration” of their environment or behavior, then the research is no longer considered “no contact” and a “full use” protocol is necessary. 
    • This form may also be used for observational studies that involve sample collection (e.g., discarded feathers, scat) which does not disturb animals.
  • Species include: typically everything from wild birds to non-human primates to marine mammals. 
  • Locations include: work in field environments and zoos.

Protocol amendments

See Modify/amend a protocol for details.

Tips for completing the protocol form

The IACUC understands no two protocols are the same, so respond to the protocol application questions as best you can. Request assistance from the IACUC office or members of the IACUC.

Do not begin activities until you have received final IACUC approval for your proposed protocol or amendment.

Last modified: Apr 30, 2024