Cayuse Human Ethics

Beginning May 1, 2021, the Office of Research Compliance Administration began to use the web-based product Cayuse Human Ethics for managing human subjects research studies. Cayuse Human Ethics is an electronic protocol management platform that is cloud-based, user-friendly, and secure.

Cayuse Human Ethics enables collaboration and increases efficiency among investigators, ORCA, and IRB committee members. It allows investigators to prepare, submit, and route human subjects research studies with secure electronic document technology.

Cayuse Human Ethics will be used to prepare and submit all initial human subjects research studies, as well as make modifications, request renewals, and report incidents.

More about Cayuse at UCSC


Log in to Cayuse Human Ethics

When to Use Cayuse Human Ethics

Cayuse Human Ethics Guide for Researchers

Help with Cayuse Human Ethics

Log in to Cayuse Human Ethics

Each investigator will need to have a Cayuse account before they can be added to a study submission. If you try to log in and get an error message, or if you know that you do not have a Cayuse account, fill out the Cayuse Account Request form.

To access Cayuse Human Ethics, go to and enter your UCSC CruzID and Gold password.

If you get a blank page upon log in, refresh your browser tab. If this does not resolve the issue, try logging into the Cayuse Research Suite at and selecting the link Cayuse IRB (Human Studies Compliance). If this does not resolve your issue email for assistance.

When to Use Cayuse Human Ethics

Submitting a Human Subjects Research Application (Initial Submission)

Administrative Check-Ins & Continuing Review (Renewal Submission)

Modifications to Existing Studies (Modification Submission)

Unanticipated Problems (UPRs), Non-Compliance, and Other Reportable Incidents (Incident Submission)

Study Closures and Withdrawals (Closure/Withdrawal Submissions)

Cayuse Human Ethics Guide for Researchers

Credit: Cayuse

Help with Cayuse Human Ethics

Resource Center

Once you've logged in to Cayuse Human Ethics, select the orange question mark icon in the bottom right corner of the window to open the Resource Center.

  • Select Show Me How To... and choose the action you want to complete, and the system will walk you through it.
  • Select Help Center to see suggested articles, or search for a support article.

Personal Assistance

For help with quick questions or issues, contact ORCA at

For individualized help with stepping through a submission, getting answers to multiple questions, or for a personal training session, sign up for a support appointment. Support appointments are available from 1:00-3:00 PM on Tuesdays and Thursdays. 

Sign up for a support appointment

If the available times don’t work for you, contact ORCA at to arrange for a one-on-one help session.