Cayuse Human Ethics
Beginning May 1, 2021, the Office of Research Compliance Administration began to use the web-based product Cayuse Human Ethics for managing human subjects research studies. Cayuse Human Ethics is an electronic protocol management platform that is cloud-based, user-friendly, and secure.
Cayuse Human Ethics enables collaboration and increases efficiency among investigators, ORCA, and IRB committee members. It allows investigators to prepare, submit, and route human subjects research studies with secure electronic document technology.
Cayuse Human Ethics will be used to prepare and submit all initial human subjects research studies, as well as make modifications, request renewals, and report incidents.
When to Use Cayuse Human Ethics
Cayuse Human Ethics Guide for Researchers
Log in to Cayuse Human Ethics
To access Cayuse Human Ethics, go to https://ucsc.cayuse424.com/rs/irb/ and enter your UCSC CruzID and Gold password.
If you get a blank page upon log in, refresh your browser tab. If this does not resolve the issue, try logging into the Cayuse Research Suite at https://ucsc.cayuse424.com/ and selecting the link Cayuse IRB (Human Studies Compliance). If this does not resolve your issue email orca@ucsc.edu for assistance.
If you try to log in and get an error message, follow the Create a Cayuse Account instructions. This error message may say "We're sorry. This account has been disabled on the Cayuse424 system." even if the account has never been created.
Create a Cayuse Account
Each investigator will need to have a Cayuse account before they can be added to a study submission. If you try to log in and get an error message, or if you know that you do not have a Cayuse account, fill out and submit the Cayuse Request form.
Study Team Members
The UCSC IRB oversees research conducted by UCSC faculty, staff, and students and will sometimes review on behalf of non-affiliated collaborators.
Some places in Cayuse Human Ethics (e.g. the "Research Personnel" section) display information about people. If the name, phone or organization (department or unit) shown for a person needs updating, use the Cayuse Request form and choose option "Update User Information". Please note that:
- Name used is the person's lived name. Instructions for changing lived name
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Email address in Cayuse needs to be the researcher's assigned CruzID@ucsc.edu, not an email alias. If a different email address than expected is shown for a researcher, please confirm their assigned CruzID before submitting a request to update information.
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Address is always in reference to the main UC Santa Cruz campus address.
When to Use Cayuse Human Ethics
Submitting a Human Subjects Research Application (Initial Submission)
Administrative Check-Ins & Continuing Review (Renewal Submission)
Modifications to Existing Studies (Modification Submission)
Unanticipated Problems (UPRs), Non-Compliance, and Other Reportable Incidents (Incident Submission)
Study Closures and Withdrawals (Closure/Withdrawal Submissions)
Cayuse Human Ethics Guide for Researchers
Credit: Cayuse
Help with Cayuse Human Ethics
Resource Center
Once you've logged in to Cayuse Human Ethics, select the orange question mark icon in the bottom right corner of the window to open the Resource Center.
- Select Show Me How To... and choose the action you want to complete, and the system will walk you through it.
- Select Help Center to see suggested articles, or search for a support article.
Personal Assistance
For help with quick questions or issues, contact ORCA at orca@ucsc.edu.
For individualized help with working through a submission, getting answers to multiple questions, or for a personal training session, sign up for a support appointment.
Sign up for a support appointment
If the available times don’t work for you, contact ORCA at orca@ucsc.edu to arrange for a one-on-one help session.
